Vaskulárna medicína 1/2025
Complications and management of pregnancy and childbirth in women with congenital fibrinogen disorders
Congenital fibrinogen disorders (CFDs) are a heterogeneous group of rare congenital quantitative and/or qualitative fibrinogen deficiencies. The spectrum of genetic variants is broad, leading to several subtypes of these disorders (afibrinogenemia, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia). Pregnancy in women with CFDs is a high-risk clinical situation with an increased tendency to miscarriages, bleeding, and thrombosis. The management of pregnancy and delivery requires a multidisciplinary approach. The article presents international guidelines for the management of pregnancy, delivery, and the postpartum period in women with CFDs.
Keywords: congenital fibrinogen disorders, pregnancy, childbirth, complications