Prostatický specifický antigen a odvozené parametry // SOLEN

Urologie pro praxi 2/2004

Prostatický specifický antigen a odvozené parametry

PROSTATE SPECIFIC ANTIGEN AND DERIVED PARAMETERS Tumour markers are important auxiliaries in the diagnosis and in monitoring the activity of oncological diseases. Urologists worldwide have since the beginning of the 80’ quite reliable marker of prostate carcinoma available in the form of prostate specific antigen (PSA). Presently is a PSA serum level considered as the most reliable marker of an early stage of disease, which has the best chance for cure. In efforts to increase PSA specificity and sensitivity, the PSA level is referred to age, prostate volume, free fraction of PSA is defined and the velocity of PSA increase in serum is determined. Authors give in the article an overview of these derived parameters and of their importance for the detection and monitoring the activity of prostate carcinoma Key words: prostate specific antigen – sensitivity, specificity, velocity, density, doubling time.