Infekce močových cest 2.0: Jak na multirezistentní bakterie? // SOLEN

Urologie pro praxi 3/2025

Urinary tract infections 2.0: How to tackle multidrug-resistant bacteria

Urinary tract infections (UTIs) are among the most common bacterial infections in both community and hospital care. UTIs are primarily caused by gram-negative bacteria, which have shown a significant increase in antibiotic resistance in recent years, particularly to beta-lactams. This resistance is mainly due to the production of various beta-lactamases, with the most significant being carbapenemases. The article provides an overview of current knowledge on different types of beta-lactam resistance and presents information on newly available beta-lactams that can overcome some of these resistance mechanisms. It also includes a practical approach to the treatment of UTIs caused by multidrug-resistant bacteria.

Keywords: urinary tract infections, antibiotics, resistence, carbapenemases.