Pediatria pre prax 3/2004
Účinky přípravků na bázi aminokyselin u kojenců s alergií / intolerancí kravského mléka – výsledky studie
THE EFFECT OF AN AMINO-ACID-BASED FORMULA IN INFANTS WITH COW´S MILK ALLERGY/INTOLERANCE AND ATOPIC DERMATITIS Cow´s milk allergy / intolerance is treated by complete avoidance of cow´s milk proteins. Because cow´s milk is an important food for infants, its avoidance may lead to an increase risk of growth impairment. Whilst there is evidence for the beneficial effects of extensively hydrolyzed cow´s milk formulae (eHF) in infants with cow´s milk allergy / intolerance, little is known about the effects of an amino-acid-based formulae (AA) in such infants. We therefore performed a prospective, controlled, multi-center trial to study the efficacy of AA in comparison with eHF, on the growth and clinical symptoms of 73 infants (median age 5,7 months) with cow´s milk allergy / intolerance and atopic dermatitis. Cow´s milk allergy / intolerance was proven in all infants by double-blind, placebo-controlled food-challenge. We observed a significant improvement in the SCORAD index in the both groups, from a mean of 24,6, at entry, to a mean of 10,7 (p < 0.0001) after 6 months. In the AA group there was a significant increase in the length standard deviation score (p < 0,04), whilst there was no difference in the eHF group. The Weight-for-length values were stable in both groups. Both an AA and eHF resulted in a significant clinical improvement in infants with an early onset of symptoms of cow´s milk allergy / intolerance. Feeding an AA resulted in improved growth compared with feeding eHF, despite similar dietary intakes, and may therefore be considered as a beneficial alternative in infants with severe cow´s milk allergy intolerance. Key words: allergy, amino-acid formula, atopy, atopic dermatitis, pediatric, food allergy, DBPCFC, extensively hydrolyzed formula, intolerance, SCORAD.
