Pediatria pre prax 4/2026

Suggested algorithm for the management of hyperCKemia in children

The elevation of serum creatine kinase (CK) and its differential diagnoses belong to the crucial knowledge for the routine clinical practice, especially in the case of paediatricians. In many patients, hyperCKemia is overdiagnosed, and in others, we can see a process of insufficient examinations that lead to delays in correct diagnoses. For proper management of hyperCKemia, it is necessary to understand the basic biochemical features, the exact definition of hyperCKemia, and the optimal timing of neurological examination. At this time, we do not have a standard guideline for the management of hyperCKemia in children, but we have developed an algorithm based on current recommendations and our clinical practice. We believed this algorithm could improve the differential diagnosis of hyperCKemia in the pediatric population.

Keywords: hyperCKemia, dystrophinopathies