Jaké mohou být důvody pro změny v dávkování antibiotik? // SOLEN

Pediatria pre prax 4/2004

Jaké mohou být důvody pro změny v dávkování antibiotik?

WHAT CAN BE THE REASONS FOR CHANGING THE DOSAGE OF ANTIBIOTICS? Out of all the antibiotics pediatricians and outpatient specialists prescribe, beta-latam antibiotics and primarily penicillin, are among the most common. During the treatment of mild to moderate infections, it is necessary for the minimum inhibitory concentration of these antibiotics for the given pathogens to be maintained in the serum for a minimum of 40?% of the dosage interval. This can be achieved with V-PNC administered every 8 hours, amoxicillin and amoxicillin in combination with clavulanic acid administered every 12 hours. Key words: V-penicillin, aminopenicillins with beta-lactamase inhibitor, beta-lactamases, resistance.