Neurológia pre prax 4/2026

Getting the diagnosis right in adults with childhood-onset epileptic encephalopathies: Lennox–Gastaut and Dravet syndromes–lessons from clinical practice

Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS) belong to the most severe developmental and epileptic encephalopathies, characterized by early onset, a lifelong disease course, and a high degree of drug-resistance. Both syndromes are associated with substantial cognitive, behavioral, and functional impairment, as well as an increased risk of serious complications. In recent years, syndrome-specific therapeutic options have expanded considerably. For both DS and LGS, fenfluramine and cannabidiol have become available as targeted treatment options, demonstrating remarkable efficacy in randomized clinical trials. The aim of this review is to summarize the key clinical characteristics of both syndromes and to briefly present our initial clinical experience with fenfluramine therapy.

Keywords: developmental and epileptic encephalopathies, Dravet syndrome, Lennox-Gastaut syndrome, fenfluramine, adult patients.