Neurológia pre prax 3/2025
Current options for prophylactic treatment of migrain
Migraine is a very common disease in the general population. It is associated with considerable disability and thus with a high socio-economic burden. Fortunately, recent years have brought fundamental new possibilities in both acute treatment of migraine attacks and prophylactic treatment, which aims to reduce the frequency and intensity of migraine attacks as much as possible. Another benefit of prophylactic treatment should optimally be the improvement of the response to acute treatment. Last but not least, prophylactic treatment should prevent the transformation of migraine from episodic to chronic form, and also eliminate the risk of developing headaches due to overuse of medication. Prophylactic migraine treatment includes many different drugs with different mechanisms of action, such as antihypertensive drugs, antidepressive medication, anticonvulsive medication, and in recent years, monoclonal antibodies against calcitonin gene-related peptide (CGRP) and gepants.
Keywords: migraine, treatment, prophylaxis, conventional drugs, monoclonal antibodies, gepants
