Neurológia pre prax 6/2025
NMOSD as a comorbidity of clinically silent Sjögren's syndrome
NMOSD (Neuromyelitis optica spectrum disorders) is a group of rare inflammatory autoimmune demyelinating diseases affecting most commonly the optic nerve, brainstem and spinal cord. During diagnostic process is necessary to rule out multiple sclerosis and myelin oligodendrocyte glycoprotein antibody-positive disease (MOGAD). NMOSD and MOGAD are still quite new diagnostic entities. Without treatment, NMOSD has a high risk of relapse and the possibility of permanent disability, especially in young people and those of working age, which is multiplied by its comorbidities. Part of the diagnostic process involves ruling out other neurological causes of the patient's current symptoms and accurately identifying the disease so that targeted therapy can be set up. The aim of this article is to highlight the fact that NMOSD can manifest itself at an older age and can also accompany systemic rheumatological diseases.
Keywords: NMOSD, neuromyelitis optica, Sjögren‘s syndrome, LETM, tocilizumab
