Neurológia pre prax 4/2026
Myoclonus – treatment: from rational pharmacotherapy to deep brain stimulation
The basis of successful myoclonus treatment lies in diagnosing the underlying causes, particularly ruling out drug-induced forms and metabolic disorders. The mainstays of symptomatic therapy are levetiracetam, valproate, and clonazepam, often in combination, while in drug-resistant cases, particularly in myoclonic dystonia, deep brain stimulation (DBS), most commonly targeting the globus pallidus internus, represents a significant therapeutic alternative. In focal forms, long-term therapy involves the administration of botulinum toxin.
Keywords: myoclonus, therapy of myoclonus, pharmacotherapy, deep brain stimulation, botulinum toxin.
