Neurológia pre prax 3/2025
Even extraordinary things could be ordinary: a case report of atypical neurodegeneration due to vascular and malnutrition components
Establishing the correct clinical diagnosis of neurodegenerative diseases can be a real challenge, particularly in rare forms with a complex clinical presentation. In such cases, neuropathological examination may reveal unexpected findings. In our case study, we observed a patient in the preterminal stage of a neurodegenerative disease that initially mimicked acute brainstem stroke, followed by hypoactive delirium, and finally frontotemporal lobar degeneration (FTLD). Neuropathological and immunohistochemical examination after autopsy revealed combined toxic-metabolic and vascular damage (chronic Wernicke’s encephalopathy and angiosclerotic encephalopathy) with a concomitant neurodegenerative disorder with tau protein deposits (FTLD-tau). Our case study highlights the importance of neuropathological verification of neurodegenerative disorders, particularly in cases with an unusual course and atypical clinical manifestation of the disease.
Keywords: neurodegenerative disease, FTLD-tau, angiosclerotic encephalopathy, Wernicke encephalopathy
