Hodnocení účinnosti léčby roztroušené sklerózy v praxi, vývoj konceptu NEDA // SOLEN

Neurológia pre prax 3/2025

Evaluating the efficacy of treatment for multiple sclerosis in the practice; development of the NEDA concept

With the advent of highly effective treatment for multiple sclerosis, it is currently possible to consider even long-term remission. The NEDA (no evidence of disease activity) concept was introduced following the evaluation of a clinical trial with natalizumab. Since then, it has been used to evaluate the effect in studies with novel drugs, allowing their comparison. It involves the assessment of relapse rates, progression, and MRI findings. It would certainly be possible to add many more items; however, even in this simple form, it is very difficult to achieve in the long term in the majority of patients.

Keywords: multiple sclerosis, NEDA concept, MRI, neurofilament light chains