Neurológia pre prax 3/2026

Gold Coast Criteria – new criteria for determination the diagnosis of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a systemic and fatal neurodegenerative disorder with degeneration of central and peripheral motoneurons, non-motor symptoms and non-interrupted progression of disease. The old diagnostic criteria are very complicated and setting of diagnosis comes late, frequently at the terminal stage of disease. The new diagnostic criteria – Gold Coast criteria – were developed by a group of specialists in 2020 and their implementation in clinical practise will shorten the time to the diagnose setting. This will be advantageous for new treatment introduction, for shortening of repeated and often demanding methods and for providing a precise information for the patient.

Keywords: amyotrophic lateral sclerosis, central and peripheral motoneuron, neurophysiological parameters, genetic investigation