Slovenská chirurgia 2/2018
Adjuvantná chemoterapia karcinómu rekta – perzistencia kontroverzií
Adjuvant chemotherapy of rectal carcinoma – persistence of controversy
Adjuvant therapy for solid tumors is designed to cure patients more often than surgery alone, and the first principles of adjuvant therapy include gaining both local and systemic control. Locally advanced rectal cancer is defined by either T3 or node positivity, and historically it has had a high risk for both local recurrence (LR) and distant recurrence. Unlike other solid tumors, local control in rectal cancer is a worthy pursuit, as a result of the morbidity associated with LR and the inability to salvage most LRs with surgery. Combined-modality therapy with chemotherapy, radiation, and surgery emerged in the 1980s and 1990s as the optimum therapy for reducing the risk of both LR and distant recurrence.
Keywords: rectal cancer, radiotherapy, chemotherapy, chemoradiotherapy, neoadjuvant therapy, adjuvant therapy
