Psychiatria pre prax 3/2018
Máme důkazy pro účinnost vysokých dávek olanzapinu?
Is there an evidence for the efficacy of high-dose olanzapine?
High-dose olanzapine is an option in the effort to break the pharmacoresistance in the treatment of schizophrenia. This is grounded both by the expert recommendations and a few randomized, double-blind trials that compared the efficacy of high-dose olanzapine (25–45 mg/d) with recommended-dose clozapine and found the same efficacy of both. High doses are generally well tolerated with the exception of the increase of weight. Therapeutic drug monitoring is recommended while titrating high doses and one has to take care of potential signs of toxicity.
Keywords: olanzapine, schizophrenia, pharmacoresistance












