Psychiatria pre prax 2/2018
Dlouhodobě působící antipsychotika v praxi
Long-acting injectable antipsychotics in clinical practice The article summarizes basic data concerning long-acting injectable or depot antipsychotics, which are currently available in the Czech Republic. They include four first generation antipsychotics (fluphenazine, flupenthixol, haloperidol and zucklopenthixol) and four second generation antipsychotics (aripiprazole, olanzapine, risperidone and paliperidone). It focuses especially on the treatment initiation and dosage regimen. Basic advantages and disadvantages of depot formulation are discussed as well as its efficacy in the prevention of relapse and the risk of adverse-events compared to oral formulation of antipsychotics.
Keywords: depot antipsychotics, LAI, schizophrenia, fluphenazine, flupenthixol, haloperidol, zucklopenthixol, risperidone, paliperidone, olanzapine, aripiprazole












