Paliatívna medicína a liečba bolesti 1e/2025
Use of chloral hydrate in pediatric home palliative care
Chloral hydrate is one of the oldest centrally acting sedatives and, despite its decline in standard clinical practice, it still holds a place in pediatric medicine. In pediatric home-based palliative care programs, it can be a suitable option in situations requiring symptomatic management of restlessness, refractory insomnia, dystonia, spasticity, or epileptic seizures. Its advantages include the possibility of enteral or rectal administration, a predictable effect, and a relatively low risk of respiratory depression compared to other sedatives. When appropriately indicated, chloral hydrate may represent a safe and effective medication for alleviating suffering during the endof- life period. This article outlines recommended dosing, associated risks, preventive measures, principles of parental education, and practical experience with its use in home settings.
Keywords: chloral hydrate, pediatric palliative care, home-based care, sedation, symptom management, refractory insomnia, dystonia, epilepsy, end-of-life care, parental education
