Onkológia 4/2025
Rapidly progressive acute liver failure in relapsed Hodgkin's lymphoma – a case report
Introduction: Liver dysfunction and fulminant liver failure (FHF) is a relatively rare manifestation of Hodkin's lymphoma. It is a rare life -threatening complication that occurs in liver infiltration by lymphoma cells. In most cases, this is a secondary liver involvement in progressing lymphoproliferative disease. Clinical manifestations, laboratory findings and imaging of liver examination methods are usually unconvincing and a liver biopsy is required to confirm. Case: The authors present a case of a 66 -year -old woman treated since November 2024 for the diagnosis of classic Hodgkin's lymphoma (CHL) type with mixed cellularity (MC) with histological verification of LU from the right axily area, clinical stage AA: IV.B - advanced, IPI -4 high risk Pathological lap: supraklavicular on both sides, mediastinal and hilous double-sided, retroperitoneal and mesentiary, present B-symptoms. After reaching a partial response, verified early relapse of the liver disability for infiltration of lymphoma cells and with the current incidence of infectious hepatitis type E (HEV). Conclusion: In diagnosis of liver dysfunction, the so-called mini-invasive intervention on the liver is of key importance, transjugular liver biopsy.
Keywords: liver damage, Hodgkin's lymphoma, hepatitis E, diagnosis, transjugular liver biopsy
