Neurológia pre prax 6/2021

Serum biomarkers in mild traumatic brain injury

More than 50 million people sustain a traumatic brain injury each year. Recently as a result of increased development of proteomics analysis and other discovery techniques, investigators have reported ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) as novel potential markers for brain injury. Blood-based brain biomarkers hold the potential to predict absence of intracranial injury and thus reduce unnecessary head CT scanning. Blood-based brain biomarkers also hold the potential to document whether a concussion occurred, especially when the history is unclear. For this reason, multi-markers analysis that presents glial and neuronal cell body damage should be performed.

Keywords: mild traumatic brain injury, GFAP, UCH-L1