Neurológia pre prax 1/2019
Sudden parkinsonism, cognitive decline and behavioral changes – drug-induced or other iatrogenic origin?
Central pontine myelinolysis and extrapontine myelinolysis are osmotic demyelination syndromes due to rapid correction of severe hyponatremia. Their clinical manifestations may often vary. We report a case of a patient with rapid onset of neuropsychiatric symptoms and parkinsonism following rapid correction of hyponatremia, with an initially considered drug-induced etiology. MRI findings compatible with central pontine and extrapontine myelinolysis, however, developed only with a delay of several weeks when clinical symptoms were already disappearing.
Keywords: central pontine myelinolysis, extrapontine myelinolysis, osmotic demyelination syndrome, parkinsonism












