Neurológia pre prax 3/2018
Kvalita života pacientů po operaci pro farmakorezistentní epilepsii
Quality of life of patients following surgery for pharmacoresistant epilepsy Objective: The aim of the study was to ascertain in what way epilepsy surgery treatment affects the quality of life of patients operated on for pharmacoresistant epilepsy. Method: Patients operated on for pharmacoresistant epilepsy completed a quality of life questionnaire (Quality of Life in Epilepsy Inventory- 89; QOLIE-89) before and after the surgery. QOLIE-89 evaluates the quality of life in 17 subscales, including the assessment of overall quality of life using the total score. We statistically evaluated whether a change in the quality of life had occurred after the surgery. Subsequently, the QOLIE-89 results were correlated with patient demographic data, including their IQ scores and psychiatric/ somatic comorbidities. Results: The study included a total of 95 patients after resection epilepsy surgery who fully and correctly completed the questionnaire prior to and at least one year after the surgery. A statistically significant improvement occurred in the following subscales: health perceptions (p < 0.001), change in health (p < 0.001), general health (p < 0.001), work/driving/social function (p < 0.001), seizure worry (p < 0.001), health discouragement (p = 0.049), medication effects (p = 0.002), and overall quality of life (p = 0.001). Following surgery, a statistically significant improvement in the total score (p = 0.008) was found. No statistically significant correlation was observed between the total score and demographic data. Conclusion: Based on our questionnaire study it can be concluded that, in the majority of patients, epilepsy surgery treatment not only leads to elimination of seizures, but also significantly contributes to improved quality of life.
Keywords: epilepsy, pharmacoresistance, epilepsy surgery, quality of life, seizure freedom
