Neurológia pre prax 1/2020
Deep brain stimulation in the treatment of dystonia
Deep brain stimulation (DBS) is an established treatment method in cases of dystonia that are not responding to peroral medication and/or targeted botulinum toxin therapy. The most frequently used surgical target for electrode insertion is internal part of globus pallidum (GPi). Young patients with short disease duration benefit most from this surgical method. Cases of isolated dystonia, generalised dystonia with phasic elements or tardive dystonia appear to respond most to DBS GPi. Many of the double-blind clinical studies show improvement of not only motor, but also non-motor symptoms of dystonia. Predictive factors for successful DBS in dystonia are subject of an ongoing research. In cases where dystonia limits the quality of life despite the optimalised pharmacotherapy should be patients without major comorbidities referred to specialised center for DBS consideration
Keywords: deep brain stimulation, DBS, dystonia
