Dermatológia pre prax 2/2019
A photoprotection position in the prevention of non-melanoma skin cancer and malignant melanoma
Chronic sun exposure is associated worldwide with an increased incidence of skin cancer,more specifically is this related to AK and NMSC. It is estimated that UVR exposure is associated with 65% of all melanomas and with 90% of NMSC. Most keratinocyte malignancies and many skin melanomas are caused by mutations in key gens and are induced by UVR. Several published studies have demonstrated the protective effect of sunscreens on malignant skin tumors when used regularly (reductiton of keratinocyte DNA damage). In the future, the photoprotective effects of sunscreens will probably be enhanced by photo corrective (repair photolyase enzymes incorporated into sunscreens). Chemopreventive strategies for cutaneous carcinogenesis are also likely to increase with regard to population aging and increasing incidence of both NMSC and malignant melanoma.
Keywords: non melanoma skin cancer, malignant melanoma, photoprotection, prevention
