Proteíny a anabolická rezistencia vo výžive kriticky chorých // SOLEN

Anestéziológia a intenzívna medicína 1/2019

Proteins and anabolic resistance in critically ill patients

In critical illness and aging, muscle protein synthesis (MPS) changes little, but muscle protein degradation (MPD) increases significantly. Anabolic resistance is present for the inability of anabolic stimuli to stimulate MPS due to decreased mTORsensitivity. Optimization of protein intake, the way of nutrition - continuous or intermittent and the possibility of influencing anabolic resistance are probably key in proper nutrition of the critically ill.

Keywords: critically ill, anabolic resistance